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KMID : 1137920070320020087
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Journal of Agricultral Medicine & Community Health
2007 Volume.32 No. 2 p.87 ~ p.96
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The Effect of Apolipoprotein E Polymorphism on Hypertension in Korean Adults
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Choi Dae-Kyung
Im Jung-Soo
Kim Geum-Ha
Park Sang-Hyun
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Abstract
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Background: Apolipoprotein E has been one of the most thoroughly studied genetic polymorphisms, particularly for its effects on lipid profiles and coronary heart disease risk. This study investigated the relationship between the apolipoprotein E polymorphism and essential hypertension in a Korean population.
Methods: The subjects (n=1,243) were participants in a population-based study in Incheon metropolitan City, Korea. The apolipoprotein E polymorphism was determined using a polymerase chain reaction method.
Results: The frequencies of the genotypes did not differ significantly between the hypertensive groups (60.0% ￥a2 / ￥a2, 30.8% ￥a2 / ￥a3, 44.4% ￥a2 / ￥a4, 33.3% ￥a3 / ￥a3, 32.3% ￥a3 / ￥a4, and 15.4% ￥a4 / ￥a4; p=0.498). After adjusting for other risk factors, genotypes were not associated with hypertension(OR 5.74, 95% CI 0.81-40.76, ￥a2 / ￥a2 vs. ￥a3 / ￥a3; OR 0.94, 95% CI 0.60-1.47, ￥a2 / ￥a3 vs. ￥a3 / ￥a3; OR 1.21, 95% CI 0.30-4.89, ￥a2 / ￥a4 vs. ￥a3 / ￥a3; OR 0.79, 95% CI 0.56-1.13, ￥a3 / ￥a4 vs. ￥a3 / ￥a3; OR 0.29, 95% CI 0.06-1.45, ￥a4 / ￥a4 vs. ￥a3 / ￥a3).
Conclusions: These findings suggest that the apolipoprotein E polymorphism is not associated with hypertension.
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KEYWORD
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Apolipoprotein E, Polymorphism, Hypertension
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